Our laboratory is composed of an eclectic group of scientists interested in dissecting the complex interactions between pathogenic bacteria and the mammalian host. Currently, we are focusing on multidrug-resistant (MDR) bacteria, which have been recognized by the World Health Organization as a serious threat to human health. We take advantage of multidisciplinary approaches and outstanding collaborations to combine techniques from bacteriology, genetics, molecular biology, biochemistry, structural biology, cellular biology, and immunology with primary ex vivo tissue culture models and a variety of murine models of infection, to address our favorite questions. Our ultimate goal is to understand the basic principles of MDR-bacterial pathogenesis as well as to develop a platform for the discovery of targets that could be exploited for the generation of much-needed therapies.
S. aureus Biology
Mechanism of cell death
Role of toxins in the pathophysiology of S. aureus infection in vivo
Structure/Function of toxins and host receptors - in collaboration with Damian Ekiert and Gira Bhabha
Development of novel biologics - in collaboration with Janssen Biotech
New vaccines against S. aureus infections